Cortex
Volume 48, Issue 2 , Pages 242-254 , February 2012

What do brain lesions tell us about theories of embodied semantics and the human mirror neuron system?

  • Analia L. Arévalo

      Affiliations

    • Center for Aphasia and Related Disorders, VA Northern California Health Care System, Martinez, CA, USA
    • Corresponding Author InformationCorresponding author. Center for Aphasia and Related Disorders, VA Northern California Health Care System, 150 Muir Road (126s), Martinez, CA 94553, USA.
    • ,
  • Juliana V. Baldo

      Affiliations

    • University of California, Davis, CA, USA
    • ,
  • Nina F. Dronkers

      Affiliations

    • Center for Aphasia and Related Disorders, VA Northern California Health Care System, Martinez, CA, USA
    • University of California, Davis, CA, USA
    • Center for Research in Language, University of California, San Diego, CA, USA

Received 17 September 2009 ,Revised 24 January 2010 ,Accepted 11 May 2010.

References 

  1. Arévalo A. Teasing apart actions and objects: A picture naming study. CRL Newsletter. May 2002;14(2):
  2. Arévalo A, Perani D, Cappa SF, Butler A, Bates E, Dronkers N. Action and object processing in aphasia: From nouns and verbs to the effect of manipulability. Brain and Language. 2007;100(1):79–94
  3. Arévalo A, Butler A, Perani D, Cappa S, Bates E. Introducing the Gesture Norming Study: A Tool for Understanding On-line Word and Picture Processing. Technical Report CRL-0401 La Jolla: University of California, San Diego, Center for Research in Language; 2004;
  4. Aziz-Zadeh L, Wilson SM, Rizzolatti G, Iacoboni M. Congruent embodied representations for visually presented actions and linguistic phrases describing actions. Current Biology. 2006;16(1):1818–1823
  5. Bates E, Andonova E, D’Amico S, Jacobsen T, Kohnert K, Lu C-C, et al. Introducing the CRL International Picture-Naming Project (CRL-IPNP). Center for Research in Language Newsletter, vol. 12(1). La Jolla: University of California San Diego; 2000;
  6. Bates E, Wilson S, Saygin AP, Dick F, Sereno M, Knight RT, et al. Voxel-based lesion-symptom mapping. Nature Neuroscience. 2003;6(1):448–450
  7. Boulenger V, Roy AC, Paulignan Y, Deprez V, Jeannerod M, Nazir TA. Cross-talk between language processes and overt motor behavior in the first 200 msec of processing. Journal of Cognitive Neuroscience. 2006;18(10):1607–1615
  8. Brett M, Leff AP, Rorden C, Ashburner J. Spatial normalization of brain images with focal lesions using cost function masking. NeuroImage. 2001;14(1):486–500
  9. Buccino G, Binkofski F, Fink GR, Fadiga L, Fogassi L, Gallese V, et al. Action observation activates premotor and parietal areas in a somatotopic manner: An fMRI study. European Journal of Neuroscience. 2001;13(1):400–404
  10. Buccino G, Riggio L, Melli G, Binkofsi F, Gallese V, Rizzolatti G. Listening to action-related sentences modulates the activity of the motor system: A combined TMS and behavioral study. Cognitive Brain Research. 2005;24(1):355–363
  11. Buxbaum LJ, Kyle KM, Menon R. On beyond mirror neurons: Internal representations subserving imitation and recognition of skilled object-related actions in humans. Cognitive Brain Research. 2005;25(1):226–239
  12. Catani M, Stuss DT. At the forefront of clinical neuroscience. Cortex. 2012;48(1):1–6
  13. Catani M, Dell'Acqua F, Vergani F, Malik F, Hodge H, Roy P, et al. Short frontal lobe connections of the human brain. Cortex. 2012;48(2):273–291
  14. Cohen J. Statistical Power Analysis for the Behavioral Sciences. 2nd ed.. Hillsdale, NJ: Earlbaum; 1988;
  15. Cohen J. A power primer. Psychological Bulletin. 1992;112(1):155–159
  16. Coltheart M. The MRC psycholinguistic database. The Quarterly Journal of Experimental Psychology. 1981;33(4):497–505
  17. Collins DL, Neelin P, Peters TM, Evans AC. Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space. Journal of Computer Assisted Tomography. 1994;18(1):192–205
  18. DeArmond SJ, Fusco MM, Dewey MM. Structure of the Human Brain: A Photographic Atlas. 2nd ed.. New York: Oxford University Press; 1976;
  19. de Zubicaray G, Postle N, McMahon K, Meredith M, Ashton R. Mirror neurons, the representation of word meaning, and the foot of the third left frontal convolution. Brain and Language. 2008;
  20. Dinstein I, Thomas C, Behrmann M, Heeger DJ. A mirror up to nature. Current Biology. 2008;18(1):R13–R18
  21. di Pellegrino G, Fadiga L, Fogassi L, Gallese V, Rizzolatti G. Understanding motor events: A neurophysiological study. Experimental Brain Research. 1992;91(1):176–180
  22. Esopenko C, Borowsky R, Cummine J, Sarty G. Mapping the semantic homunculus: A functional and behavioural analysis of overt semantic generation. Brain Topography. 2008;21(1):22–35
  23. Fernandino L, Iacoboni M. Are cortical motor maps based on body parts or coordinated actions? Implications for embodied semantics. Brain and Language. 2010;112(1):44–53
  24. Ferrari PF, Gallese V, Rizzolatti G, Fogassi L. Mirror neurons responding to the observation of ingestive and communicative mouth actions in the monkey ventral premotor cortex. European Journal of Neuroscience. 2003;17(1):1703–1714
  25. Fischer MH, Zwaan RA. Embodied language: A review of the role of the motor system in language comprehension. The Quarterly Journal of Experimental Psychology. 2008;61(6):825–850
  26. Friedrich FJ, Egly R, Rafal RD, Beck D. Spatial attention deficits in humans: A comparison of superior parietal and temporal–parietal junction lesions. Neuropsychology. 1998;12(1):193–207
  27. Gallese V, Fadiga L, Fogassi L, Rizzolatti G. Action recognition in the premotor cortex. Brain. 1996;119(1):593–609
  28. Gallese V, Lakoff G. The brain’s concepts: The role of the sensory-motor system in reason and language. Cognitive Neuropsychology. 2005;22(1):455–479
  29. Gazzola V, Keysers C. The observation and execution of actions share motor and somatosensory voxels in all tested subjects: Single-subject analyses of unsmoothed fMRI data. Cerebral Cortex. 2009;19(1):1239–1255
  30. Hauk O, Johnsrude I, Pulvermüller F. Somatotopic representation of action words in human motor and premotor cortex. Neuron. 2004;41(1):301–307
  31. Johnson-Frey SH. Stimulation through simulation? Motor imagery and functional reorganization in hemiplegic stroke patients. Brain and Cognition. 2004;55(1):328–331
  32. Kemmerer D, Gonzalez-Castillo J. The two-level theory of verb meaning: An approach to integrating the semantics of action with the mirror neuron system. Brain and Language. 2010;112(1):54–76
  33. Kemmerer D, Gonzalez Castillo J, Talavage T, Patterson S, Wiley C. Neuroanatomical distribution of five semantic components of verbs: Evidence from fMRI. Brain and Language. 2008;107(1):16–43
  34. Kertesz A. Western Aphasia Battery. New York: Grune and Stratton; 1982;
  35. Kimberg DY, Coslett HB, Schwartz MF. Power in voxel-based lesion-symptom mapping. Journal of Cognitive Neuroscience. 2007;19(1):1067–1080
  36. Knight RT, Scabini D, Woods DL, Clayworth C. The effects of lesions of superior temporal gyrus and inferior parietal lobe on temporal and vertex components of the human AEP. Electroencephalography and Clinical Neurophysiology. 1988;70(1):499–509
  37. MacWhinney B. The emergence of grammar from embodiment. In:  MacWhinney B editors. The Emergence of Language. Mahwah, NJ: Lawrence Erlbaum; 1999;p. 213–256
  38. Mahon BZ, Caramazza A. Concepts and categories: A cognitive neuropsychological perspective. Annual Review of Psychology. 2009;60(1):27–51
  39. Mahon BZ, Milleville S, Negri GAL, Rumiati RI, Martin A, Caramazza A. Action-related properties of objects shape object representations in the ventral stream. Neuron. 2007;55(1):507–520
  40. Möttönen R, Järveläinen J, Sams M, Hari R. Viewing speech modulates activity in the left SI mouth cortex. NeuroImage. 2004;24(1):731–737
  41. Negri GAL, Rumiati RI, Zadini A, Ukmar M, Mahon BZ, Caramazza A. What is the role of motor simulation in action and object recognition? Evidence from Apraxia. Cognitive Neuropsychology. 2007;24(8):795–816
  42. Nishitani N, Hari R. Temporal dynamics of cortical representation for action. Proceedings of the National Academy of Sciences USA. 2000;97(1):913–918
  43. Nishitani N, Hari R. Viewing lip forms: Cortical dynamics. Neuron. 2002;36(1):1211–1220
  44. Penfield W, Boldrey E. Somatic motor and sensory representation in the cerebral cortex of man as studied by electrical stimulation. Brain. 1958;60(1):389–443
  45. Pobric G, Hamilton AFde C. Action understanding requires the left inferior frontal cortex. Current Biology. 2006;16(1):524–529
  46. Postle N, McMahon KL, Ashton R, Meredith M, de Zubicaray GI. Action word meaning representations in cytoarchitectonically defined primary and premotor cortices. NeuroImage. 2008;43(1):634–644
  47. Pulvermüller F. Brain mechanisms linking language and action. Nature Reviews Neuroscience. 2005;6(1):576–582
  48. Pulvermüller F, Berthier ML. Aphasia therapy on a neuroscience basis. Aphasiology. 2008;22(6):563–599
  49. Pulvermüller F, Harle M, Hummel F. Walking or talking: Behavioral and neurophysiological correlates of action verb processing. Brain and Language. 2001;78(1):143–168
  50. Pulvermüller F, Kherif F, Hauk O, Mohr B, Nimmo-Smith I. Distributed cell assemblies for general lexical and category-specific semantic processing as revealed by fMRI cluster analysis. Human Brain Mapping. 2009;30(12):3837–3850
  51. Rizzolatti G, Craighero L. The mirror-neuron system. Annual Review of Neuroscience. 2004;27(1):169–192
  52. Rizzolatti G, Fadiga L, Matelli M, Bettinardi V, Paulesu E, Perani D, et al. Localization of grasp representations in humans by PET: 1. Observation versus execution. Experimental Brain Research. 1996;111(1):246–252
  53. Rizzolatti G, Fogassi L, Gallese V. Neurophysiological mechanisms underlying the understanding and imitation of action. Nature Reviews Neuroscience. 2001;2(1):661–670
  54. Rizzolatti G, Luppino G. The cortical motor system. Neuron. 2001;31(1):889–901
  55. Rorden C, Brett M. Stereotaxic display of brain lesions. Behavioural Neurology. 2000;12(1):191–200
  56. Rosci C, Chiesa V, Laiacona M, Capitani E. Apraxia is not associated to a disproportionate naming impairment for manipulable objects. Brain and Cognition. 2003;53(1):412–415
  57. Sanes JN, Schieber MH. Orderly somatotopy in primary motor cortex: Does it exist?. NeuroImage. 2001;13(1):968–974
  58. Sato M, Mengarelli M, Riggio L, Gallese V, Buccino G. Task related modulation of the motor system during language processing. Brain and Language. 2008;105(2):83–90
  59. Scorolli C, Borghi AM. Sentence comprehension and action: Effector specific modulation of the motor system. Brain Research. 2006;1130(1):119–124
  60. Schubotz RI, von Cramon DY. Functional–anatomical concepts of human premotor cortex: Evidence from fMRI and PET studies. NeuroImage. 2003;20(1):S120–S131
  61. Sharma N, Pomeroy VM, Baron J-C. Motor imagery. A backdoor to the motor system after stroke?. Stroke. 2006;37(1):1941–1952
  62. Sharma N, Simmons LH, Jones S, Day DJ, Carpenter A, Pomeroy VM, et al. Motor imagery after subcortical stroke: A functional magnetic resonance imaging study. Stroke. 2009;40(1):1315–1324
  63. Shtyrov Y, Hauk O, Pulvermüller F. Distributed neuronal networks for encoding category-specific semantic information: The mismatch negativity to action words. European Journal of Neuroscience. 2004;19(4):1083–1092
  64. Siri S, Tettamanti M, Cappa SF, Della Rosa P, Saccuman C, Scifo P, et al. The neural substrate of naming events: Effects of processing demands but not of grammatical class. Cerebral Cortex. 2008;18(1):171–177
  65. Székely A, Bates E. Objective visual complexity as a variable in studies of picture naming. CRL Newsletter. July 2000;12(2):
  66. Székely A, D’Amico S, Devescovi A, Federmeier K, Herron D, Iyer G, et al. Timed action and object naming. Cortex. 2005;41(1):7–26
  67. Tettamanti M, Buccino G, Saccuman MC, Gallese V, Danna M, Scifo P, et al. Listening to action-related sentences activated fronto-parietal motor circuits. Journal of Cognitive Neuroscience. 2005;17(2):273–281
  68. Tomasino B, Fink GR, Sparing R, Dafotakis M, Weiss PH. Action verbs and the primary motor cortex: A comparative TMS study of silent reading, frequency judgments, and motor imagery. Neuropsychologia. 2008;46(1):1915–1926
  69. Tranel D, Kemmerer D, Adolphs R, Damasio H, Damasio AR. Neural correlates of conceptual knowledge for actions. Cognitive Neuropsychology. 2003;20(1):409–432
  70. Tremblay C, Robert M, Pascual-Leone A, Lepore F, Nguyen DK, Carmant L, et al. Action observation and execution: Intracranial recordings in a human subject. Neurology. 2004;63(1):937–938
  71. Turella L, Pierno AC, Tubaldi F, Castiello U. Mirror neurons in humans: Consisting or confounding evidence?. Brain and Language. 2009;108(1):10–21

PII: S0010-9452(10)00157-7

doi: 10.1016/j.cortex.2010.06.001

Cortex
Volume 48, Issue 2 , Pages 242-254 , February 2012

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