Cortex
Volume 46, Issue 7 , Pages 811-820 , July 2010

Language, cognition and the cerebellum: Grappling with an enigma

  • Alan Beaton

      Affiliations

    • Department of Psychology, University of Swansea, Wales, UK
    • Corresponding Author InformationCorresponding author. Department of Psychology, University of Swansea, Wales, UK.
  • ,
  • Peter Mariën

      Affiliations

    • Department of Neurology, ZNA Middelheim Hospital, Antwerp, Belgium

References 

  1. Ackermann H, Wildgruber D, Daum I, Grodd W. Does the cerebellum contribute to cognitive aspects of speech production? A functional magnetic resonance imaging (fMRI) study in humans. Neuroscience Letters. 1998;247:187–190
  2. Akshoomoff NA, Courchesne E, Press GA, Iragui V. Contribution of the cerebellum to neuropsychological functioning: Evidence from a case of cerebellar degenerative disorder. Neuropsychologia. 1992;30:315–328
  3. Albus JA. Theory of cerebellar function. Mathematical Biosciences. 1971;10:25–61
  4. Allin M, Matsumoto H, Santhouse AM, Nosarti C, Alasady MH, Stexard AL, et al. Cognitive and motor functions and the size of the cerebellum in adolescents born very pre-term. Brain. 2001;124:60–66
  5. Anderson NE, Posner JB, Sidtis JJ, Moeller JR, Strother SC, Dhawan V, et al. The metabolic anatomy of paraneoplastic cerebellar degeneration. Annals of Neurology. 1988;23:533–540
  6. André-Thomas J. Cerebellar Functions. [Herring WC, Trans.] Journal of Nervous and Mental Diseases Monograph Series 12. New York: Journal of Nervous and Mental Diseases Publishing Company; 1912;
  7. Annett J, Annett M, Hudson PT, Turner A. The control of movement in the preferred and non-preferred hands. The Quarterly Journal of Experimental Psychology. 1979;31:641–652
  8. Babinski J. De l'asynergie cérébelleuse. Revue Neurologique. 1899;7:806–816
  9. Babinski J. Asynergie et inertie cerebelleuse. Revue Neurologique. 1906;14:685–686
  10. Babinski J. Sur le rôle du cervelet dans les actes volitonnels nécessitant une succession rapide de mouvements-diadococinésie. Revue Neurologique. 1902;10:1013–1015
  11. Baillieux H, De Smet HJ, Dobbeleir A, Paquier PF, De Deyn PP, Mariën P. Cognitive and affective disturbances following focal cerebellar damage in adults: A neuropsychological and SPECT study. Cortex. 2010;46(7):869–879
  12. Baillieux H, De Smet HJ, Lesage G, Paquier P, De Deyn PP, Mariën P. Neurobehavioral alterations in an adolescent following posterior fossa tumor resection. The Cerebellum. 2006;5:289–295
  13. Baillieux H, Weyns F, Paquier P, De Deyn PP, Mariën P. Posterior fossa syndrome after a vermian stroke: A new case and review of the literature. Pediatric Neurosurgery. 2007;43:386–395
  14. Baron JC, Bousser MG, Comar D, Castaigne P. “Crossed cerebellar diaschisis” in human supratentorial brain infarction. Transactions of the American Neurological Association. 1981;105:459–461
  15. Beaton AA. Dyslexia and the cerebellar deficit hypothesis. Cortex. 2002;38:479–490
  16. Beaton AA. The determinants of handedness. In:  Hugdahl K,  Davidson RJ editor. Brain Asymmetry. 2nd ed.. Cambridge MA: MIT Press; 2003;p. 105–158
  17. Beaton AA. Dyslexia, Reading and the Brain: A Sourcebook of Biological and Psychological Research. Hove: Psychology Press; 2004;
  18. Beaton AA. Anatomy of manual skill. Cortex. 2004;40:228–229
  19. Bellebaum C, Daum I. Cerebellar involvement in executive control. The Cerebellum. 2007;6:184–192
  20. Bellebaum C and Daum I. Mechanisms of cerebellar involvement in associative learning. Cortex, in press.
  21. Bishop DV. Cerebellar abnormalities in developmental dyslexia: Cause, correlate or consequence?. Cortex. 2002;38:491–498
  22. Bloedel JR. Functional heterogeneity: How does the cerebellum operate?. Behavioral and Brain Sciences. 1992;15:666–678
  23. Bloedel JR. ‘Involvement in’ versus ‘Storage of’. Trends in Neurological Science. 1993;16:451–452
  24. Bolk L. Das Cerebellum der Saugetiere. Jena: Fisher; 1906;
  25. Botez MI, Botez TH, Leveille J, Lambert R. Cerebello-cerebral diaschisis and the role of the cerebellum. Neurology. 1990;40:173
  26. Bracke-Tolkmitt R, Linden A, Canavan AGM, Rockstroh B, Scholz E, Wessel K, et al. The cerebellum contributes to mental skills. Behavioral Neuroscience. 1989;103:442–446
  27. Brindley GS. The use made by the cerebellum of the information that it receives from the sense organs. International Brain Research Organization. 1964;3:80
  28. Broich K, Hartman A, Biersack H, Horn R. Crossed cerebello-cerebral diaschisis in a patient with cerebellar infarction. Neuroscience Letters. 1987;83:7–12
  29. Cantalupo C, Hopkins W. The cerebellum and its contribution to complex tasks in higher primates: A comparative perspective. Cortex. 2010;46(7):821–830
  30. Catsman-Berrevoets CE, Aarsen FK. The spectrum of neurobehavioural deficits in the Posterior Fossa Syndrome in children after cerebellar tumour surgery. Cortex. 2010;46(7):933–946
  31. Chambers WW, Sprague JM. Functional localization in the cerebellum. I. Organization in longitudinal cortico-nuclear zones and their contribution to the control of posture, both extrapyramidal and pyramidal. The Journal of Comparative Neurology. 1955;103:105–129
  32. Chambers WW, Sprague JM. Functional localization in the cerebellum. II. Somatotopic organization in cortex and nuclei. AMA Archives of Neurology and Psychiatry. 1955;74:653–680
  33. Cole M. Dysprosody due to posterior fossa lesions. Transactions of the American Neurological Association. 1971;96:151–154
  34. Courchesne E, Allen G. Prediction and preparation, fundamental functions of the cerebellum. Learning & Memory. 1997;4:1–35
  35. Daum I, Ackermann H. Cerebellar contribution to cognition. Behavioral Brain Research. 1995;67:201–210
  36. Davis EE, Pitchford NJ, Jaspan T, McArthur D, Walker D. Development of cognitive and motor function following cerebellar tumour injury sustained in early childhood. Cortex. 2010;46(7):919–932
  37. Decety J, Sjoholm H, Ryding E, Stenberg G, Ingvar DH. The cerebellum participates in mental activity: Tomographic measurements of regional cerebral blood flow. Brain Research. 1990;535:313–317
  38. De Schutter E, Maex R. The cerebellum: Cortical processing and theory. Current Opinion in Neurobiology. 1996;6:759–764
  39. De Smet HJ, Baillieux H, Catsman-Berrevoets C, De Deyn PP, Mariën P, Paquier PF. Postoperative motor speech production in children with the syndrome of ‘cerebellar’ mutism and subsequent dysarthria: A critical review. European Journal of Paediatric Neurology. 2007;11:193–207
  40. De Smet HJ, Baillieux H, De Deyn PP, Mariën P, Paquier PF. The cerebellum and language: The story so far. Folia Phoniatrica et Logopaedica. 2007;59:165–170
  41. De Smet HJ, Baillieux H, Wackenier P, De Praeter A, Engelborghs S, Paquier PF, et al. Long-term cognitive deficits following posterior fossa tumour resection: A follow-up neuropsychological and functional neuroimaging study. Neuropsychology. 2009;23:694–704
  42. Durisko C, Fiez JA. Functional activation in the cerebellum during working memory and simple speech tasks. Cortex. 2010;46(7):896–906
  43. Fawcett AJ, Nicolson RI. Automatisation deficits in balance for dyslexic children. Perceptual and Motor Skills. 1992;75:507–529
  44. Fiez JA, Petersen SE, Cheney MK, Raichle ME. Impaired non-motor learning and error detection associated with cerebellar damage. Brain. 1992;115:155–178
  45. Flourens P. Phrenology Examined. Translated from the Second Edition of 1844, by Charles de Lucena Meigs. Philadelphia: Hogan & Thompson; 1846;
  46. Flourens P. Recherches Experimentales sur les Propriétés et les Functions du Systeme Nerveux dans les Animaux Vertebrés. Paris: Crevot; 1824;
  47. Gall FJ, Vimont J, Broussais JV. On the Functions of the Cerebellum. Translated from the French by George Combe Edinburgh: Maclachlan & Stewart; 1838;
  48. Gao JH, Parsons LM, Bower JM, Xiong JH, Li JQ, Fox PT. Cerebellum implicated in sensory acquisition and discrimination rather than motor control. Science. 1996;272:545–547
  49. Glickstein M. Motor skills but not cognitive tasks. Trends in Neurosciences. 1993;11:450–451
  50. Glickstein M. Thinking about the cerebellum. Brain. 2006;129:288–290
  51. Glickstein M. What does the cerebellum really do?. Current Biology. 2007;17:824–827
  52. Glickstein M, Doron K. Cerebellum: Connections and functions. The Cerebellum. 2008;7:589–594
  53. Glickstein M, Waller J, Baizer JS, Brown B, Timmann D. Cerebellum lesions and finger use. The Cerebellum. 2005;4:189–197
  54. Glickstein M, Strata P, Voogd J. Review: Cerebellum: History. Neuroscience. 2009;162:549–559
  55. Glickstein M, Sultan F, and Voogd J. Functional localization in the cerebellum. Cortex, in press.
  56. Gordon N. Speech, language, and the cerebellum. International Journal of Disorders of Communication. 1996;31:359–367
  57. Gottwald B, Mihajlovic Z, Wilde B, Mehdorn HM. Does the cerebellum contribute to specific aspects of attention?. Neuropsychologia. 2003;41:1452–1460
  58. Gottwald B, Wilde B, Mihajlovic Z, Mehdorn HM. Evidence for distinct cognitive deficits after focal cerebellar lesions. Journal of Neurology, Neurosurgery and Psychiatry. 2004;74:1524–1531
  59. Gowers WR. Brain and general functional diseases. In:  Gowers WR editors. Diseases of the Nervous System. Philadelphia: P. Blakiston and Son; 1888;p. 497
  60. Hokkanen LSK, Kauranen V, Roine RO, Salonen O, Kotila M. Subtle cognitive deficits after cerebellar infarcts. European Journal of Neurology. 2006;13:161–170
  61. Holmes G. The symptoms of acute cerebellar injuries due to gunshot injuries. Brain. 1917;40:461–535
  62. Holmes G. The Croonian lectures on the clinical symptoms of cerebellar disease and their interpretations. Lecture I–IV. The Lancet. 1922;ii:1177–1182, 1132–1137, 1159–1165, 1111–1115
  63. Holmes G. The cerebellum of man. Brain. 1939;62:1–30
  64. Ito M. Neural systems controlling movements. Trends in Neurosciences. 1986;9:515–518
  65. Ito M. A new physiological concept on cerebellum. Revue Neurologique. 1990;146:564–569
  66. Ito M. Movement and thought: Identical control mechanisms by the cerebellum. Trends in Neurosciences. 1993;16:448–450
  67. Ito M. Control of mental activities by internal models in the cerebellum. Nature Reviews. Neuroscience. 2008;9:304–313
  68. Ivry R. Cerebellar involvement in the explicit representation of temporal information. Annals of the New York Academy of Sciences. 1993;682:214–230
  69. Ivry RB, Fiez JA. Cerebellar contributions to cognition and imagery. In:  Gazzaniga M editors. The New Cognitive Neurosciences. 2nd ed.. Cambridge, MA: MIT Press; 2000;p. 999–1011
  70. Ivry R, Keele SW. Timing functions of the cerebellum. Journal of Cognitive Neuroscience. 1989;1:136–152
  71. Ivry R, Spencer RM, Zelaznik HN, Diedrichsen J. The cerebellum and event timing. In:  Highstein SM,  Thach WT editor. The Cerebellum: Recent Developments in Cerebellar Research. vol. 978:New York: New York Academy of Sciences; 2002;p. 302–317
  72. Jäncke L, Specht K, Mirzazade S, Peters M. The effect of finger-movement speed of the dominant and the subdominant hand on cerebellar activation: A functional magnetic resonance imaging study. NeuroImage. 1999;9:497–507
  73. Jansen A, Flöel A, Van Randenborgh J, Konrad C, Rotte M, Förster AF, et al. Crossed cerebro-cerebellar language dominance. Human Brain Mapping. 2005;24:165–172
  74. Junck L, Gilman S, Rothley JM, Betley AT, Koeppe RA, Hichwa RD. A relationship between metabolism in frontal lobes and cerebellum in normal subjects studied with PET. Journal of Cerebral Blood Flow and Metabolism. 1988;8:774–782
  75. Leggio MG, Chiricozzi FR, Clausi S, Tedesco AM, and Molinari M. The neuropsychological profile of cerebellar damage: The sequencing hypothesis. Cortex, in press.
  76. Leiner HC, Leiner AL, Dow RS. Does the cerebellum contribute to mental skills?. Behavioral Neuroscience. 1986;100:443–454
  77. Leiner HC, Leiner AL, Dow RS. Reappraising the cerebellum: What does the hindbrain contribute to the forebrain?. Behavioral Neuroscience. 1989;103:998–1008
  78. Leiner HC, Leiner AL, Dow RS. Cognitive and language functions of the human cerebellum. Trends in Neurosciences. 1993;16:444–447
  79. Leuret F. Anatomie comparée du système nerveux considéré dans ses rapports avec l'intelligence, vol. 1. Paris: Baillière, 1839.
  80. Luciani L. Il cervelletto: nuovi studi di fisiologia normale e patologica. Florence: Successori le Monnier; 1891;
  81. Manni E, Petrosini L. Luciani's work on the cerebellum a century later. Trends in Neurosciences. 1997;20:112–116
  82. Manni E, Petrosini L. A century of cerebellar somatotopy: A debated representation. Nature Reviews. Neuroscience. 2004;5:241–249
  83. Manto M and Lorivel T. Cognitive repercussions of hereditary cerebellar disorders. Cortex, in press.
  84. Mariën P, Baillieux H, De Smet HJ, Engelborghs S, Wilssens I, Paquier P, et al. Cognitive, linguistic and affective disturbances following a right superior cerebellar artery infarction: A case study. Cortex. 2009;45:527–536
  85. Mariën P, Engelborghs S, De Deyn PP. Cerebellar neurocognition: A new avenue. Acta Neurologica Belgica. 2001;101:96–106
  86. Mariën P, Engelborghs S, Fabbro F, De Deyn PP. The lateralized linguistic cerebellum: A review and new hypothesis. Brain and Language. 2001;79:580–600
  87. Mariën P, Engelborghs S, Pickut B, De Deyn PP. Aphasia following cerebellar damage: Fact or fallacy?. Journal of Neurolinguistics. 2000;13:145–171
  88. Mariën P, Saerens J, Nanhoe R, Moens E, Nagels G, Pickut B, et al. Cerebellar induced aphasia: Case report of cerebellar induced prefrontal aphasic language phenomena supported by SPECT findings. Journal of the Neurological Sciences. 1996;144:34–43
  89. Mariën P, Verhoeven J. Cerebellar involvement in motor speech planning: Some further evidence from foreign accent syndrome. Folia Phoniatrica et Logopaedica. 2007;59:210–217
  90. Mariën P, Verhoeven J, Brouns R, De Witte L, Dobbeleir A, De Deyn PP. Apraxic agraphia following a right cerebellar hemorrhage. Neurology. 2007;69:926–929
  91. Mariën P, Verhoeven J, Engelborghs S, Rooker S, Pickut BA, De Deyn PP. A role for the cerebellum in motor speech planning: Evidence from foreign accent syndrome. Clinical Neurology and Neurosurgery. 2006;208:518–522
  92. Marr D. A theory of cerebellar cortex. The Journal of Physiology. 1969;202:437–470
  93. Martin WRW, Raichle ME. Cerebellar blood flow and metabolism in cerebral hemisphere infarction. Annals of Neurology. 1983;14:168–176
  94. Marvel CL, Desmond JE. The contributions of cerebro-cerebellar circuitry to executive verbal working memory. Cortex. 2010;46(7):880–895
  95. McManus IC, Cornish KM. Commentary. Fractionating handedness in mental retardation: What is the role of the cerebellum?. Laterality. 1997;2:81–90
  96. Metter EJ, Kempler D, Jackson CA, Hanson WR, Riege WH, Camras LR, et al. Cerebellar glucose metabolism in chronic aphasia. Neurology. 1987;37:1599–1606
  97. Miall RC, Weir DJ, Wolpert DM, Stein JF. Is the cerebellum a Smith Predictor?. Journal of Motor Behavior. 1993;25:203–216
  98. Mills CK, Weisenburg TH. Cerebellar symptoms and cerebellar localization. JAMA: The Journal of the American Medical Association. 1914;63:1813–1818
  99. Molinari M, Leggio MG. Cerebellar information processing and visuospatial functions. The Cerebellum. 2007;6:214–220
  100. Moruzzi G. Sham rage and localized autonomic responses elicited by cerebellar stimulation in the acute thalamic cat. Proceedings of the XVII International Congress of Physiology (Oxford). 1947;114–115
  101. Murdoch BE. The cerebellum and language: Historical perspective and review. Cortex. 2010;46(7):858–868
  102. Nicolson RI, Fawcett AJ. Procedural learning difficulties: Reuniting developmental disorders?. Trends in Neurosciences. 2007;30:135–141
  103. Nicolson RI and Fawcett AJ. Developmental disorders, procedural learning and the cerebellum: A neural systems approach. Cortex, in press.
  104. Nicolson RI, Fawcett AJ, Dean P. Time estimation deficits in developmental dyslexia: Evidence for cerebellar involvement. Proceedings of the Royal Society: Biological Sciences. 1995;259:43–47
  105. Nicolson RI, Fawcett AJ, Dean P. Developmental dyslexia: The cerebellar deficit hypothesis. Trends in Neurosciences. 2001;24:514–516
  106. Paquier PF, Mariën P. A synthesis of the role of the cerebellum in cognition. Aphasiology. 2005;19:3–19
  107. Paradiso S, Andreasen NC, O'Leary DS, Arndt S, Robinson R. Cerebellar size and cognition: Correlations with IQ, verbal memory and motor dexterity. Neuropsychiatry, Neuropsychology and Behavioral Neurology. 1997;1:1–8
  108. Peters M. Handedness and its relation to other indices of cerebral lateralization. In:  Davidson RJ,  Hugdahl K editor. Brain Asymmetry. Cambridge, MA: MIT Press; 1995;p. 183–214
  109. Petersen SE, Fiez JA. The processing of single words studied with positron emission tomography. Annual Review of Neuroscience. 1993;16:509–530
  110. Ravizza SM, McCormick CA, Schlerf JE, Justus T, Ivry RB, Fiez JA. Cerebellar damage produces selective deficits in verbal working memory. Brain. 2006;129:306–320
  111. Raymond JL, Lisberger SG, Mauk MD. The cerebellum: A neuronal learning machine?. Science. 1996;272:1126–1131
  112. Richter S, Kaiser O, Hein-Kropp C, Dimitrova A, Gizewski E, Beck A, et al. Preserved verb generation in patients with cerebellar atrophy. Neuropsychologia. 2004;42:1235–1246
  113. Rolando L. Saggio sopra la vera struttura del cervello dell'uomo e degli animali e sopra le funzioni del sistema nervosa. Sassari, Stamperìa Da S.S.R.M. Privilegiata, 1809.
  114. Schmahmann JD. An emerging concept: The cerebellar contribution to higher function. Archives of Neurology. 1991;48:1178–1187
  115. Schmahmann JD. Disorders of the cerebellum: Ataxia, dysmetria of thought, and the cognitive affective syndrome. The Journal of Neuropsychiatry and Clinical Neurosciences. 2004;16:367–378
  116. Schmahmann JD. The primary motor cerebellum is in the anterior lobe but not the posterior lobe. Evidence from stroke patients. Neurology. 2007;68:A357
  117. Schmahmann JD, Caplan D. Cognition, emotion and the cerebellum. Brain. 2006;129:290–292
  118. Schmahmann JD, Sherman JC. The cerebellar cognitive affective syndrome. Brain. 1998;121:561–579
  119. Schoch B, Dimitrova A, Gizewski ER, Timmann D. Functional localization in the human cerebellum based on voxelwise statistical analysis: A study of 90 patients. NeuroImage. 2006;30:36–51
  120. Sherrington SC. The Integrative Action of the Nervous System. New York: Charles Scribner's Sons; 1906;
  121. Silveri MC, Leggio MG, Molinari M. The cerebellum contributes to linguistic production: A case of agrammatic speech following a right cerebellar lesion. Neurology. 1994;44:2047–2050
  122. Simon JR. Steadiness, handedness, and hand preference. Perceptual and Motor Skills. 1964;18:203–206
  123. Snider RS. Functional alterations of cerebral sensory areas by the cerebellum. Progress in Brain Research. 1967;25:322–333
  124. Snyder PJ, Bilder RM, Wu H, Bogerts B, Lieberman JA. Cerebellar volume asymmetries are related to handedness: A quantitative MRI study. Neuropsychologia. 1995;33:407–419
  125. Sönmezoglu K, Sperling B, Henriksen T, Tfelt-Hansen P, Lassen NA. Reduced contralateral hemispheric flow measured by SPECT in cerebellar lesions: Crossed cerebral diaschisis. Acta Neurologica Scandinavica. 1993;87:275–280
  126. Stein JF, Glickstein M. Role of the cerebellum in visual guidance of movement. Physiological Reviews. 1992;72:967–1017
  127. Stoodley CJ, Schmahmann JD. The cerebellum and language: Evidence from patients with cerebellar degeneration. Brain and Language. 2009;110:149–153
  128. Stoodley CJ, Schmahmann JD. Functional topography in the human cerebellum: A meta-analysis of neuroimaging studies. NeuroImage. 2009;44:489–501
  129. Stoodley CJ, Schmahmann JD. Evidence for topographic organization in the cerebellum of motor control versus cognitive and affective processing. Cortex. 2010;46(7):831–844
  130. Stoodley CJ and Stein JF. The cerebellum and dyslexia. Cortex, in press.
  131. Strick PL, Dum RP, Fiez JA. Cerebellum and nonmotor function. Annual Review of Neuroscience. 2009;32:413–434
  132. Tavano A, Borgatti R. Evidence for a link among cognition, language and emotion in cerebellar malformations. Cortex. 2010;46(7):907–918
  133. Tesak J, Code C. Milestones in the History of Aphasia. Theories and Protagonists. Hove: Psychology Press; 2008;
  134. Thach WT, Goodkin HP, Keating JG. The cerebellum and the adaptive coordination of movement. Annual Review of Neuroscience. 1992;15:403–442
  135. Thach WT. On the specific role of the cerebellum in motor learning and cognition: Clues from PET activation and lesion studies in man. Behavioral and Brain Sciences. 1996;19:411–431
  136. Timmann D, Daum I. Cerebellar contributions to cognitive functions: A progress report after two decades of research. The Cerebellum. 2007;6:159–162
  137. Timmann D, Drepper J, Calabrese S, Bürgerhoff K, Maschke M, Kolb FP, et al. Use of sequence information in associative learning in control subjects and cerebellar patients. The Cerebellum. 2004;3:75–82
  138. Timmann D, Drepper J, Frings M, Maschke M, Richter S, Gerwig M, et al. The human cerebellum contributes to motor, emotional and cognitive associative learning. A review. Cortex. 2010;46(7):845–857
  139. Timmann D, Drepper J, Maschke M, Kolb FP, Boring D, Thilmann AF, et al. Motor deficits cannot explain impaired cognitive associative learning in cerebellar patients. Neuropsychologia. 2002;40:788–800
  140. Vlachos F, Papathanasiou I, Andreou G. Cerebellum and reading. Folia Phoniatrica et Logopaedica. 2007;59:177–183
  141. Walshe FMR. The significance of the voluntary element in the genesis of cerebellar ataxy. Brain. 1927;50:377–390
  142. Watson PJ. Nonmotor functions of the cerebellum. Psychological Bulletin. 1978;85:944–967
  143. Weisenburg TH. Cerebellar localization and its symptomatology. Brain. 1927;50:357–377

PII: S0010-9452(10)00083-3

doi: 10.1016/j.cortex.2010.02.005

Cortex
Volume 46, Issue 7 , Pages 811-820 , July 2010