Cortex
Volume 46, Issue 5 , Pages 637-649 , May 2010

New insights into feature and conjunction search: II. Evidence from Alzheimer's disease

  • Gillian Porter

      Affiliations

    • Department of Experimental Psychology, University of Bristol, UK
    • Corresponding Author InformationCorresponding author. Department of Experimental Psychology, University of Bristol, 12a Priory Road, Bristol BS8 1TU, UK.
    • ,
  • Ute Leonards

      Affiliations

    • Department of Experimental Psychology, University of Bristol, UK
    • ,
  • Gordon Wilcock

      Affiliations

    • Department of Care of the Elderly, University of Bristol, The BRACE Centre, Blackberry Hill Hospital, Fishponds, Bristol, UK
    • Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, UK
    • ,
  • Judy Haworth

      Affiliations

    • Department of Care of the Elderly, University of Bristol, The BRACE Centre, Blackberry Hill Hospital, Fishponds, Bristol, UK
    • ,
  • Tom Troscianko

      Affiliations

    • Department of Experimental Psychology, University of Bristol, UK
    • ,
  • Andrea Tales

      Affiliations

    • Department of Experimental Psychology, University of Bristol, UK
    • Department of Care of the Elderly, University of Bristol, The BRACE Centre, Blackberry Hill Hospital, Fishponds, Bristol, UK

Received 7 February 2008 ,Revised 30 September 2008 ,Accepted 23 April 2009.

References 

  1. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. DSM-IV. 4th ed. Washington (DC), 1994.
  2. Amieva H, Phillips LH, Della Sala S, Henry JD. Inhibitory functioning in Alzheimer's disease. Brain. 2004;127:949–964
  3. Baddeley AD. Working Memory. Oxford: Oxford University Press; 1986;
  4. Baddeley AD, Baddeley HA, Bucks RS, Wilcock GK. Attentional control in Alzheimer's disease. Brain. 2001;124:1492–1508
  5. Baddeley AD, Bressi S, Della Sala S, Logie R, Spinnler H. The decline of working memory in Alzheimer's disease: A longitudinal study. Brain. 1991;114:2521–2542
  6. Baddeley AD, Logie R, Bressi S, Della Sala S, Spinnler H. The decline of working memory in Alzheimer's disease. Brain. 1986;114:2521–2542
  7. Beatty J. Task-evoked pupillary responses, processing load, and the structure of processing resources. Psychological Bulletin. 1982;91:276–292
  8. Beatty J, Lucero-Wagoner B. The pupillary system. In:  Cacioppo JT,  Tassinary LG,  Berntson GG editor. Handbook of Psychophysiology. Cambridge, UK: Cambridge University Press; 2000;p. 14–162
  9. Body LCP, de Rosa E. Cholinergic influences on feature binding. Behavioural Neuroscience. 2007;121:264–276
  10. Bradley MM, Miccoli L, Escrig MA, Lang PJ. The pupil as a measure of emotional arousal and autonomic activation. Psychophysiology. 2008;45:602–607
  11. Craik FIM. Age differences in remembering. In:  Squire LR,  Butters N editor. Neuropsychology of Memory. New York, London: The Guilford Press; 1984;p. 3–12
  12. Delgado-Garcia JM, Yajeya J, Navarro-Lopez JD. A cholinergic mechanism underlies persistent neural activity necessary for eye fixation. Progress in Brain Research. 2006;154:211–224
  13. Duncan J, Humphreys G. Visual search and stimulus similarity. Psychological Review. 1989;96:433–458
  14. Festa EK, Insler RZ, Salmon DP, Paxton J, Hamilton JM, Heindel WC. Neocortical disconnectivity disrupts sensory integration in Alzheimer's disease. Neuropsychology. 2005;19:728–738
  15. Foldi NS, Lobosco JJ, Schaefer LA. The effect of attentional dysfunction in Alzheimer's disease: Theoretical and practical implications. In:  Helm-Estabrooks N,  Bernstein Ratner N,  Murray LL editor. Seminars in Speech and Language, vol. 23. Attention: Its Neuroanatomical Bases, Forms, Disorders, Assessments, and Treatment in Adults with Specific Neurological Disorders. New York: Thieme Medical Publishers, Inc; 2002;p. 139–150
  16. Foldi NS, Schaefer LA, White REC, Johnson RJR, Berger JT, Carney MT, et al. Effects of graded levels of physical similarity and density on visual selective attention in patients with Alzheimer's disease. Neuropsychology. 2005;19:5–17
  17. Folstein MF, Folstein SE, Mchugh PR. Mini-mental state: A practical method for grading the state of patients for the clinician. Journal of Psychiatric Research. 1975;12:189–198
  18. Foster JK, Behrmann M, Stuss DT. Visual attention deficits in Alzheimer's disease: Simple versus conjoined feature search. Neuropsychology. 1999;13:223–245
  19. Fotiou F, Fountoulakis KN, Tsolaki M, Goulas A, Palikaras A. Changes in pupil reaction to light in Alzheimer's disease patients: A preliminary report. International Journal of Psychophysiology. 2000;37:111–120
  20. Goldwater BC. Psychological significance of pupillary movements. Psychological Bulletin. 1972;77:340–355
  21. Granholm E, Asarnow RF, Sarkin AJ, Dykes KL. Pupillary responses index cognitive resource limitations. Psychophysiology. 1996;33:457–461
  22. Granholm E, Morris S, Galasko D, Shults C, Rogers E, Vukov B. Tropicamide effects on pupil size and pupillary light reflexes in Alzheimer's and Parkinson's disease. International Journal of Psychophysiology. 2003;47:95–115
  23. Granholm E, Morris SK, Sarkin AJ, Asarnow RF, Jeste DV. Pupillary responses index overload of working memory resources in schizophrenia. Journal of Abnormal Psychology. 1997;106:458–465
  24. Granholm E, Morris S, Asarnow RF, Chock D, Jeste DV. Accelerated age-related decline in processing resources in schizophrenia: Evidence from pupillary responses recorded during the span of apprehension task. Journal of the International Neuropsychological Society. 2000;6:30–43
  25. Hanyu H, Hirao K, Shimizu S, Kanetaka H, Sakurai H, Iwamoto T. Phenylephrine and pilocarpine eye drop test for dementia with Lewy bodies and Alzheimer's disease. Neuroscience Letters. 2007;414:174–177
  26. Hasselmo ME. The role of acetylcholine in learning and memory. Current Opinion in Neurobiology. 2006;16:710–715
  27. Hooge ITC, Erkelens CJ. Control of fixation during a simple search task. Perception and Psychophysics. 1996;58:969–976
  28. Hooge ITC, Erkelens CJ. Peripheral vision and oculomotor control during visual search. Vision Research. 1999;39:1567–1575
  29. Kahneman D, Beatty J. Pupil diameter and load on memory. Science. 1966;154:1583–1585
  30. Kahneman D. Attention and Effort. Englewood Cliffs, New Jersey: Prentice-Hall Inc; 1973;
  31. Levinoff EJ, Li KZH, Murtha S, Chertkow H. Selective attention impairments in Alzheimer's disease: evidence for dissociable components. Neuropsychology. 2004;18:580–588
  32. Linnebur SA, Ruscin JM. Cholinesterase inhibitor use in geriatric outpatients with dementia. American Journal of Health-System Pharmacy. 2005;62:923–926
  33. Loewenfeld IE. The Pupil: Anatomy, Physiology and Clinical Applications. Iowa State University Press/Ames; 1993;
  34. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA work group under the auspices of the department of health and human services task force on Alzheimer's disease. Neurology. 1984;34:939–945
  35. Morris RG. Working memory in Alzheimer-type dementia. Neuropsychology. 1994;8:544–554
  36. Mosimann UP, Felblinger J, Ballinari P, Hess CW, Muri RM. Visual exploration behaviour during clock reading in Alzheimer's disease. Brain. 2004;127:431–438
  37. Navarro-Lopez JD, Yajeya J, Delgado-Garcia JM. A cholinergic mechanism for eye fixation. Journal of Molecular Neuroscience. 2006;30:125–127
  38. Nobili L, Sannita WG. Cholinergic modulation, visual function and Alzheimer's dementia. Vision Research. 1997;37:3559–3571
  39. Parkhurst D, Law K, Niebur E. Modelling the role of salience in the allocation of overt visual attention. Vision Research. 2002;42:107–123
  40. Perry RJ, Hodges JR. Attention and executive deficits in Alzheimer's disease. Brain. 1999;122:383–404
  41. Pierce GL, Henderson JM. The control of fixation duration during scene perception. Visual Cognition. 2006;15:108–112
  42. Porter G, Tales A, Troscianko T, Wilcock G, Haworth J, Leonards U. New insights into feature and conjunction search: I. Evidence from pupil size, eye movements and ageing. Cortex. 2010;46:621–636
  43. Porter G, Troscianko T, Gilchrist ID. Effort during visual search and counting: insights from pupillometry. Quarterly Journal of Experimental Psychology. 2007;60:211–229
  44. Prettyman R, Bitsios P, Szabadi E. Altered pupillary size and darkness and light reflexes in Alzheimer's disease. Journal of Neurology, Neurosurgery and Psychiatry. 1997;62:665–668
  45. Rösler A, Mapstone ME, Hays AK, Mesulam M-M, Rademaker A, Gitelman DR, et al. Alterations of visual search strategy in Alzheimer's disease and aging. Neuropsychology. 2000;14:398–408
  46. Rösler A, Mapstone M, Hays-Wicklund A, Gitelman DR, Weintraub S. The zoom lens of focal attention in visual search: Changes in aging and Alzheimer's disease. Cortex. 2005;41:5612–5619
  47. Salthouse TA. Aging and measures of processing speed. Biological Psychology. 2000;54:35–54
  48. Scinto LFM, Daffner KR, Dressler D, Rasnil BI, Rentz D, Weintraub S, et al. A potential non-invasive neurobiological test for Alzheimer's disease. Science. 1994;266:1051–1054
  49. Sebastian MV, Menor J, Elosua MR. Attentional dysfunction of the central executive in AD: Evidence from dual task and perseveration errors. Cortex. 2006;42:1015–1020
  50. Shafiq-Antonacci R, Maruff P, Masters C, Currie J. Spectrum of saccade system function in Alzheimer disease. Archives of Neurology. 2003;60:1272–1278
  51. Steinhauer SR, Siegle GJ, Condray R, Pless M. Sympathetic and parasympathetic innervation of pupillary dilation during sustained processing. International Journal of Psychophysiology. 2004;52:77–86
  52. Tales A, Butler SR, Fossey J, Gilchrist ID, Jones RW, Troscianko T. Visual search in Alzheimer's disease: A deficiency in processing conjunctions of features. Neuropsychologia. 2002;1440:1–9
  53. Tales A, Muir J, Jones R, Bayer A, Snowden RJ. The effects of saliency and task difficulty on visual search performance in ageing and Alzheimer's disease. Neuropsychologia. 2004;42:335–345
  54. Tales A, Porter G. Visual attention-related processing in Alzheimer's disease. Reviews in Clinical Gerontology. 2009;
  55. Tales A, Troscianko T, Lush D, Haworth J, Wilcock GK, Butler SR. The pupillary light reflex in ageing and Alzheimer's disease. Aging Clinical and Experimental Research. 2001;13:473–478
  56. Treisman A. Features and objects: The fourteenth Bartlett memorial lecture. The Quarterly Journal of Experimental Psychology. 1988;40A:201–237
  57. Treisman A, Gelade G. A feature integration theory of attention. Cognitive Psychology. 1980;12:97–136
  58. Wolfe JM. Visual search. In:  Pashler H editors. Attention. Psychology Press; 1998;p. 13–73
  59. Zelinsky GJ, Sheinberg DL. Eye movements during parallel-serial visual search. Journal of Experimental Psychology, Human Perception and Performance. 1997;23:244–262

PII: S0010-9452(09)00164-6

doi: 10.1016/j.cortex.2009.04.014

Cortex
Volume 46, Issue 5 , Pages 637-649 , May 2010

Article Tools

* Image Usage & Resolution