Cortex
Volume 46, Issue 4 , Pages 451-461 , April 2010

Cognitive reserve modulates task-induced activations and deactivations in healthy elders, amnestic mild cognitive impairment and mild Alzheimer's disease

  • Beatriz Bosch

      Affiliations

    • Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clínic de Barcelona, Catalonia, Spain
    • ,
  • David Bartrés-Faz

      Affiliations

    • Department de Psiquiatria i Psicobiologia Clinica, Universitat de Barcelona, Catalonia, Spain
    • Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Catalonia, Spain
    • Corresponding Author InformationCorresponding author. Departament de Psiquiatria i Psicobiologia Clinica, Facultat de Medicina, Universitat de Barcelona, Casanova 143, 08036 Barcelona, Spain.
    • ,
  • Lorena Rami

      Affiliations

    • Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clínic de Barcelona, Catalonia, Spain
    • Department de Psiquiatria i Psicobiologia Clinica, Universitat de Barcelona, Catalonia, Spain
    • ,
  • Eider M. Arenaza-Urquijo

      Affiliations

    • Department de Psiquiatria i Psicobiologia Clinica, Universitat de Barcelona, Catalonia, Spain
    • ,
  • Davinia Fernández-Espejo

      Affiliations

    • Department de Psiquiatria i Psicobiologia Clinica, Universitat de Barcelona, Catalonia, Spain
    • Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Catalonia, Spain
    • ,
  • Carme Junqué

      Affiliations

    • Department de Psiquiatria i Psicobiologia Clinica, Universitat de Barcelona, Catalonia, Spain
    • Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Catalonia, Spain
    • ,
  • Cristina Solé-Padullés

      Affiliations

    • Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clínic de Barcelona, Catalonia, Spain
    • ,
  • Raquel Sánchez-Valle

      Affiliations

    • Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clínic de Barcelona, Catalonia, Spain
    • Department de Psiquiatria i Psicobiologia Clinica, Universitat de Barcelona, Catalonia, Spain
    • ,
  • Núria Bargalló

      Affiliations

    • Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Catalonia, Spain
    • Radiology Service, Hospital Clínic de Barcelona, Catalonia, Spain
    • ,
  • Carles Falcón

      Affiliations

    • Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Catalonia, Spain
    • CIBER-BBN, Barcelona, Catalonia, Spain
    • ,
  • José Luis Molinuevo

      Affiliations

    • Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clínic de Barcelona, Catalonia, Spain
    • Department de Psiquiatria i Psicobiologia Clinica, Universitat de Barcelona, Catalonia, Spain

Received 10 November 2008 ,Revised 20 April 2009 ,Accepted 6 May 2009.

References 

  1. Anchisi D, Borroni B, Franceschi M, Kerrouche N, Kalbe E, Beuthien-Beumann B, et al. Heterogenity of brain glucose metabolism in mild cognitive impairment and clinical progression to Alzheimer disease. Archives of Neurology. 2005;62:1728–1733
  2. Andrews-Hanna JR, Snyder AZ, Vincent JL, Lustig C, Head D, Raichle MC, et al. Disruption of large-scale brain systems in advanced aging. Neuron. 2007;56:924–935
  3. Bartrés-Faz D, Solé-Padullés C, Junqué C, Rami L, Bosch B, Bargalló N, et al. Interactions of cognitive reserve with regional brain anatomy and brain function during a working memory task in healthy elders. Biological Psychology. 2009;80:256–259
  4. Binder JR, Frost JA, Hammeke TA, Bellgowan PS, Springer JA, Kaufman JN, et al. Human temporal lobe activation by speech and nonspeech sounds. Cerebral Cortex. 2000;10:512–528
  5. Bozzali M, Filippi M, Magnani G, Cercignani M, Franceschi M, Schiatti E, et al. The contribution of voxel-based morphometry in staging patients with mild cognitive impairment. Neurology. 2006;67:453–460
  6. Buckner R, Andrews-Hanna JR, Schacter DL. The brain's default network. Anatomy, function, and relevant to disease. Annals of the New York Academy of Sciences. 2008;1124:1–3
  7. Casanova R, Srikanth R, Baer A, Laurienti PJ, Burdette JH, Hayasaka S, et al. Biological parametric mapping: A statistical toolbox for multimodality brain image analysis. NeuroImage. 2007;34:137–143
  8. Celone KA, Calhoun VD, Dickerson BC, Atri A, Chua EF, Miller SL, et al. Alterations in memory networks in mild cognitive impairment and Alzheimer's disease: And independent component analysis. The Journal of Neuroscience. 2006;26:10222–10231
  9. Chételat G, Desgranges B, de la Sayette V, Viader F, Eustache F, Baron JC. Mild cognitive impairment. Can FDG-PET predict who is to rapidly convert to Alzheimer's disease?. Neurology. 2003;60:1374–1377
  10. Damoiseaux JS, Beckmann CF, Sanz Arigita EJ, Barkhof F, Scheltens Ph, Stam CJ, et al. Reduced resting-state brain activity in the “default network” in normal aging. Cerebral Cortex. 2008;18:1856–1864
  11. Daselaar SM, Prince SE, Cabeza R. When less means more: Deactivations during encoding that predict subsequent memory. NeuroImage. 2004;23:921–927
  12. Dehaene-Lambertz G, Dehaene S, Hertz-Pannier L. Functional neuroimaging of speech perception in infants. Science. 2002;298:2013–2015
  13. Fernández-Espejo D, Junqué C, Vendrell P, Bernabeu M, Roig T, Bargalló N, et al. Cerebral response to speech in vegetative and minimally conscious states after traumatic brain injury. Brain Injury. 2008;22:882–890
  14. Fox MC, Snyder AZ, Vincent JL, Corbetta M, Van Essen DC, Raichle ME. The human brain is intrinsically organized into dynamic, anticorrelated functional networks. Proceedings of the National Academy of Sciences USA. 2005;102:9673–9678
  15. Goodglass H, Kaplan E. The Assessment of Aphasis and Related Disorders. Philadelphia: Lea Febiger; 1972;
  16. Greicius MD, Srivastava G, Reiss AL, Menon V. Default-mode network activity distinguishes Alzheimer's disease from healthy aging: evidence from functional MRI. Proceedings of the National Academy of Sciences USA. 2004;101:4637–4642
  17. Greicius MD, Krasnow B, Reiss AL, Menon V. Functional connectivity in the resting brain: A network analysis of the default mode hypothesis. Proceedings of the National Academy of Sciences USA. 2003;100:253–258
  18. Greicius MD, Supekar K, Menon V, Dougherty RF. Resting state functional connectivity reflects structural connectivity in the default mode network. Cerebral Cortex. 2009;19:72–78
  19. Habeck C, Hilton HJ, Zarahn E, Flynn J, Moeller J, Stern Y. Relation of cognitive reserve and task performance to expression of regional covariance networks in an event-related fMRI study of nonverbal memory. NeuroImage. 2003;20:1723–1733
  20. Harrison BJ, Pujol J, López-Sola M, Hernández-Ribas R, Deus J, Ortiz H, et al. Consistency and functional specialization in the default mode brain network. Proceedings of the National Academy of Sciences USA. 2008;105:9781–9786
  21. Helzner EP, Scarmeas N, Cosentino S, Portet F, Stern Y. Leisure activity and cognitive decline in incident Alzheimer disease. Archives of Neurology. 2007;64:1749–1754
  22. Kidron D, Black SE, Stanchev P, Buck B, Szalai JP, Parker J, et al. Quantitative MR volumetry in Alzheimer's disease. Topographic markers and the effects of sex and education. Neurology. 1997;49:1504–1512
  23. Lezak D, Howieson DB, Loring DW, Hannay HJ, Fischer JS. Neuropsychological Assessment. New York: Oxford University Press; 2004;91–97
  24. Lustig C, Snyder AZ, Bhakta M, O'Brien KC, McAvoy M, Raichle ME, et al. Functional deactivations: Change with age and dementia of the Alzheimer type. Proceedings of the National Academy of Sciences USA. 2003;100:14504–14509
  25. Mashal N, Faust M, Hendler T, Jung-Beeman M. Hemispheric differences in processing the literal interpretation of idioms: Converging evidence from behavioral and fMRI studies. Cortex. 2008;44:848–860
  26. McKiernan KA, Kaufman JN, Kucera-Thompson , Binder JR. A parametric manipulation of factors affecting task-induced deactivation in functional neuroimaging. Journal of Cognitive Neuroscience. 2003;15:394–408
  27. Minoshima S, Giordani B, Berent S, Frey KA, Foster NL, Kuhl DE. Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease. Annals of Neurology. 1997;42:85–94
  28. Perneczky R, Drzezga A, Diehl-Schmid J, Schmid G, Wohlschlager A, Kars S, et al. Schooling mediates brain reserve in Alzheimer's disease: Findings of fluoro-deoxy-glucose-positron emission tomography. Journal of Neurology, Neurosurgery and Psychiatry. 2006;77:1060–1063
  29. Person J, Lin J, Larsson A, Ingvar M, Sleeger K, Van Broeckhoven C, et al. Altered deactivation in individuals with genetic risk for Alzheimer's disease. Neuropsychology. 2008;46:1679–1687
  30. Persson J, Lustig C, Nelson JK, Reuter-Lorenz P. Age differences in deactivation: A link to cognitive control?. Journal of Cognitive Neuroscience. 2007;19:1021–1032
  31. Petrella JR, Wang L, Krishnan S, Slavin MJ, Prince SE, Tran TT, et al. Cortical deactivation in mild cognitive impairment: High-field-strength functional MR imaging. Neuroradiology. 2007;245:224–234
  32. Petrella JR, Prince SE, Wang L, Hellegers C, Doraiswamy PM. Prognostic value of posteromedial cortex deactivation in mild cognitive impairment. PLoS ONE. 2007;2:1104
  33. Pfeffer RI, Kurosaki TT, Harrah CH, Chance JM, Filos S. Measurement of functional activities in older adults in the community. Journal of Gerontology. 1982;37:323–329
  34. Rami L, Gomez-Anson B, Sanchez-Valle R, Bosch B, Monte GC, Llado A, et al. Longitudinal study of amnesic patients at high risk for Alzheimer's disease: Clinical, neuropsychological and magnetic resonance spectroscopy features. Dementia and Geriatric Cognitive Disorders. 2007;24:274–279
  35. Rombouts SARB, Barkhof F, Goekoop R, Stam CJ, Scheltens P. Altered resting state networks in mild cognitive impairment and mild Alzheimer's disease: An fMRI study. Human Brain Mapping. 2005;26:231–239
  36. Scahill RI, Schott JM, Stevens JM, Rossor MN, Fox NC. Mapping the evolution of regional atrophy in Alzheimer's disease: Unbiased analysis of fluid-registered serial MRI. Proceedings of the National Academy of Sciences USA. 2002;99:4135–4137
  37. Scarmeas N, Albert SM, Manly JJ, Stern Y. Education and rates of cognitive decline in incident Alzheimer's disease. Journal of Neurology, Neurosurgery and Psychiatry. 2006;77:308–316
  38. Scarmeas N, Zarahn E, Anderson KE, Hilton J, Flynn J, Van Heertum RL, et al. Cognitive reserve modulates functional brain responses during memory tasks: A PET study in healthy young and elderly subjects. NeuroImage. 2003;19:1215–1227
  39. Scarmeas N, Zarahn E, Anderson KE, Honing LS, Park A, Hilton J, et al. Cognitive reserve-mediated modulation of positron emission tomographic activations during memory tasks in Alzheimer disease. Archives of Neurology. 2004;61:73–78
  40. Scarmeas N. Lifestyle patterns and cognitive reserve. In:  Stern Y editors. Cognitive Reserve. Theory and Applications. New York: Taylor & Francis; 2007;p. 187–206
  41. Snowdon D. Healthy aging and dementia: Findings from the Nun Study. Annals of Internal Medicine. 2003;139:450–454
  42. Solé-Padullés C, Bartrés-Faz D, Junqué C, Vendrell P, Rami L, Clemente IC, et al. Brain structure and function related to cognitive reserve variables in normal aging, mild cognitive impairment and Alzheimer's disease. Neurobiology of Aging. 2009;30:1114–1124
  43. Springer MV, McIntosh AR, Winocur G, Grady CL. The relation between brain activity during memory tasks and years of education in young and older adults. Neuropsychology. 2005;19:181–192
  44. Staff R, Murray AD, Deary IJ, Whalley LJ. What provides cerebral reserve. Brain. 2004;127:1191–1199
  45. Stern Y, Zarahn E, Hilton HJ, Flynn J, DeLaPaz R, Rakitin B. Exploring the neural basis of cognitive reserve. Journal of Clinical and Experimental Neuropsychology. 2003;25:691–701
  46. Stern Y. What is cognitive reserve? Theory and research application of the reserve concept. Journal of the International Neuropsychological Society. 2002;8:448–460
  47. Stern Y, Albert S, Tang MX, Tsai WY. Rate of memory decline in AD is related to education and occupation: Cognitive reserve?. Neurology. 1999;53:1942–1947
  48. Stern Y, Habeck C, Moeller J, Scarmeas N, Anderson KE, Hilton HJ, et al. Brain networks associated with cognitive reserve in healthy young and old adults. Cerebral Cortex. 2005;15:394–402
  49. Tyler LK, Stamatakis EA, Post B, Randall B, Marslen-Wilson W. Temporal and frontal systems in speech comprehension: An fMRI study of past tense processing. Neuropsychologia. 2005;43:1963–1974
  50. Uchiyama Y, Toyoda H, Honda M, Yoshida H, Kochiyama T, Ebe K, et al. Functional segregation of the inferior frontal gyrus for syntactic processes: A functional magnetic-resonance imaging study. Neuroscience Research. 2008;61:309–318
  51. Valenzuela MJ, Sachdev P. Brain reserve and dementia: A systematic review. Psychological Medicine. 2005;35:1–14
  52. Valenzuela MJ, Sachdev P, Wen W, Chen X, Brodaty H. Lifespan mental activity predicts diminished rate of hippocampal atrophy. PLoS ONE. 2008;3:2598
  53. Waiter GD, Fox HC, Murray AD, Starr JM, Staff RT, Bourne VJ, et al. Is retaining the youthful functional anatomy underlying speed of information processing a signature of successful cognitive ageing? An event-related fMRI study of inspection time performance. NeuroImage. 2008;41:581–595
  54. Wilson RS, Bennett DA, Gilley DW, Beckett LA, Barnes LL, Evans DA. Premorbid reading activity and patterns of cognitive decline in Alzheimer disease. Archives of Neurology. 2000;57:1718–1723

PII: S0010-9452(09)00157-9

doi: 10.1016/j.cortex.2009.05.006

Cortex
Volume 46, Issue 4 , Pages 451-461 , April 2010

Article Tools

* Image Usage & Resolution