Cortex
Volume 44, Issue 9 , Pages 1265-1270 , October 2008

Repeat and Point: Differentiating semantic dementia from progressive non-fluent aphasia

  • John R. Hodges

      Affiliations

    • Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, UK
    • Prince of Wales Medical Research Institute, Randwick, Sydney, NSW, Australia
    • Corresponding Author InformationCorresponding author. Prince of Wales Medical Research Institute, Barker Street, Randwick, Sydney, NSW 2031, Australia.
  • ,
  • Marina Martinos

      Affiliations

    • Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, UK
  • ,
  • Anna M. Woollams

      Affiliations

    • Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, UK
  • ,
  • Karalyn Patterson

      Affiliations

    • Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, UK
  • ,
  • Anna-Lynne R. Adlam

      Affiliations

    • Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, UK

Received 17 January 2007 ,Revised 28 June 2007 ,Accepted 31 August 2007.

References 

  1. Adlam A-LR, Patterson K, Rogers TT, Nestor PJ, Salmond CH, Acosta-Cabronero J, et al. Semantic dementia and fluent primary progressive aphasia: two sides of the same coin?. Brain. 2006;129:3066–3080
  2. Bozeat S, Lambon Ralph MA, Patterson K, Garrard P, Hodges JR. Non-verbal semantic impairment in semantic dementia. Neuropsychologia. 2000;38:1207–1215
  3. Brun A, Englund B, Gustafson L, Passant U, Mann DMA, Neary D, et al. Clinical and neuropathological criteria for frontotemporal dementia. The Lund Manchester groups. Journal of Neurology, Neurosurgery and Psychiatry. 1994;57:416–418
  4. Croot K, Patterson K, Hodges JR. Single word production in non-fluent progressive aphasia. Brain and Language. 1998;61:226–273
  5. Folstein MF, Robins LN, Helzer JE. The mini-mental state examination. Archives of General Psychiatry. 1983;40:812
  6. Garrard P, Lambon Ralph MA, Watson PC, Powis J, Patterson K, Hodges JR. Longitudinal profiles of semantic impairment for living and nonliving concepts in dementia of Alzheimer's type. Journal of Cognitive Neuroscience. 2001;13:892–909
  7. Garrard P, Patterson K, Watson PC, Hodges JR. Category-specific semantic loss in dementia of Alzheimer's type: functional–anatomical correlations from cross-sectional analyses. Brain. 1998;121:633–646
  8. Gathercole SE, Willis CS, Baddeley AD, Emslie H. The children's test of nonword repetition: a test of phonological working memory. Memory. 1994;2:103–127
  9. Grossman M, Mickanin J, Onishi K, Hughes E, D'Esposito M, Ding X-S, et al. Progressive nonfluent aphasia: language, cognitive, and pet measures contrasted with probable Alzheimer's disease. Journal of Cognitive Neuroscience. 1996;8:135–154
  10. Hodges JR, Miller BL. The classification, genetics and neuropathology of frontotemporal dementia (ftd). Introduction to the special topic papers: part i. Neurocase. 2001;7:31–35
  11. Hodges JR, Miller BL. The neuropsychology of frontal variant ftd and semantic dementia. Introduction to the special topic papers: part ii. Neurocase. 2001;7:113–121
  12. Hodges JR, Patterson K. Non-fluent progressive aphasia and semantic dementia: a comparative neuropsychological study. Journal of the International Neuropsychological Society. 1996;2:511–524
  13. Hodges JR, Patterson K, Oxbury S, Funnell E. Semantic dementia: progressive fluent aphasia with temporal lobe atrophy. Brain. 1992;115:1783–1806
  14. Jefferies E, Jones R, Bateman D, Ralph MA. When does word meaning affect immediate serial recall in semantic dementia?. Cognitive and Behavioral Neurology. 2004;4:20–42
  15. Karbe H, Kertesz A, Polk M. Profiles of language impairment in primary progressive aphasia. Archives of Neurology. 1993;50:193–201
  16. Knibb JA, Xuereb JH, Patterson K, Hodges JR. Clinical and pathological characterisation of progressive aphasia. Annals of Neurology. 2006;59:156–165
  17. Neary D, Snowden JS, Gustafson L, Passant U, Stuss D, Black S, et al. Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology. 1998;51:1546–1554
  18. Osterrieth PA. Le test de copie d'une figure complexe: Contribution a l'étude de la perception et de la mémoire. Archives de Psychologie. 1944;30:206–256
  19. Patterson K, Graham N, Hodges JR. The impact of semantic memory loss on phonological representations. Journal of Cognitive Neuroscience. 1994;6:57–69
  20. Perry RJ, Hodges JR. Differentiating frontal and temporal variant frontotemporal dementia from Alzheimer's disease. Neurology. 2000;54:2277–2284
  21. Ratnavalli E, Brayne C, Dawson K, Hodges JR. The prevalence of frontotemporal dementia. Neurology. 2002;58:1615–1621
  22. Rogers TT, Ivanoiu A, Patterson K, Hodges JR. Semantic memory in Alzheimer's disease and the fronto-temporal dementias: a longitudinal study of 236 patients. Neuropsychology. 2006;20:319–335
  23. Tree JJ, Perfect TJ, Hirsch KW, Copstick S. Deep dysphasic performance in non-fluent progressive aphasia: a case study. Neurocase. 2001;7:473–488
  24. Warrington EK, James M. The Visual Object and Space Perception Battery. Bury St Edmunds: Thames Valley Test Company; 1991;

 Disclosure: the authors have reported no conflicts of interest.

PII: S0010-9452(07)00155-4

doi: 10.1016/j.cortex.2007.08.018

Cortex
Volume 44, Issue 9 , Pages 1265-1270 , October 2008